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KMID : 1102220220410010102
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Kidney Research and Clinical Practice
2022 Volume.41 No. 1 p.102 ~ p.113
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Long-term risk of all-cause mortality in live kidney donors: a matched cohort study
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Kang Eun-Jeong
Park Se-Hoon
Park Jina
Kim Yae-Rim
Park Min-Su
Kim Kwang-Soo
Kim Hyo-Jeong
Han Mi-Yeun
Cho Jang-Hee
Lee Jung-Pyo
Lee Sik
Kim Soo-Wan
Park Sang-Min
Chae Dong-Wan
Chin Ho-Jun
Kim Yong-Chul
Kim Yon-Su
Choi In-Sun
Lee Ha-Jeong
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Abstract
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Background: Long-term outcomes of live kidney donors remain controversial, although this information is crucial for selecting potential donors. Thus, this study compared the long-term risk of all-cause mortality between live kidney donors and healthy control.
Methods: We performed a retrospective cohort study including donors from seven tertiary hospitals in South Korea. Persons who underwent voluntary health screening were included as controls. We created a matched control group considering age, sex, era, body mass index, baseline hypertension, diabetes, estimated glomerular filtration rate, and dipstick albuminuria. The study outcome was progression to end-stage kidney disease (ESKD), and all-cause mortality as identified in the linked claims database.
Results: We screened 1,878 kidney donors and 78,115 health screening examinees from 2003 to 2016. After matching, 1,701 persons remained in each group. The median age of the matched study subjects was 44 years, and 46.6% were male. Among the study subjects, 2.7% and 16.6% had underlying diabetes and hypertension, respectively. There were no ESKD events in the matched donor and control groups. There were 24 (1.4%) and 12 mortality cases (0.7%) in the matched donor and control groups, respectively. In the age-sex adjusted model, the risk for all-cause mortality was significantly higher in the donor group than in the control group. However, the significance was not retained after socioeconomic status was included as a covariate (adjusted hazard ratio, 1.82; 95% confidence interval, 0.87-3.80).
Conclusion: All-cause mortality was similar in live kidney donors and matched non-donor healthy controls with similar health status and socioeconomic status in the Korean population.
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KEYWORD
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End-stage kidney disease, Living donors, Mortality, Risk assessment, Prognosis
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